HIV-1 Accessory Proteins Adapt Cellular Adaptors to Facilitate Immune Evasion
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چکیده
منابع مشابه
HIV-1 Accessory Proteins Adapt Cellular Adaptors to Facilitate Immune Evasion
As obligate intracellular parasites, viruses must gain entry into target cells and utilize the host cellular machinery for production of viral progeny. After entering the cell and localizing to an intracellular niche, the virus sheds its capsid, replicates its genome, transcribes its RNA, translates its protein components, and assembles the components to form new progeny virions that can infect...
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Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef allele...
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The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with t...
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proteins into clathrin pathways. Because of their key The clathrin pathway is the principal route for receprole in linking sorted proteins with the clathrin coat, the tor-mediated endocytosis and growth factor downregassembly factors are now referred to as heterotetramulation. Heterotetrameric clathrin adaptors directly eric clathrin adaptors. link the clathrin coat with cargo transmembrane pro...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2014
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1003851